Born in Wesson, MS, in 1918, Houston Stackhouse’s first instrument was the harmonica. Throughout the 1930s Stackhouse played around Mississippi with the Mississippi Sheiks and Robert Johnson. Stackhouse taught the slide guitar to his cousin, Robert Nighthawk, and the two would play together on Mother’s Best Flower Hour and the King Biscuit Time show, both broadcast on KFFA in Helena, AR. Playing on KFFA, Stackhouse was brought into contact with James Elmore, Muddy Waters, Little Walter, Jimmy Rogers, Roosevelt Sykes and Earl Hooker. Electric guitar became Stackhouse’s full-time instrument.